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Midazolam, offered under the brand Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to deal with extreme agitation. It works by causing drowsiness, reducing anxiety, and triggering a loss of capability to produce brand-new memories.

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The drug does not cause a specific to become unconscious, merely to be sedated. It is likewise beneficial for the treatment of extended (lasting over 5 minutes) seizures. Midazolam can be provided by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek.

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When given intravenously, it normally starts working within five minutes; when injected into a muscle, it can take fifteen minutes to start working. Results last between one and six hours. The 1997 Duran album Medazzaland is called in reference to Midazolam.

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Side effects can include a reduction in efforts to breathe, low high blood pressure, and sleepiness. Tolerance to its impacts and withdrawal syndrome might happen following long-lasting usage. Paradoxical results, such as increased activity, can happen especially in children and older people.

There is proof of threat when used during pregnancy however no evidence of damage with a single dose throughout breastfeeding. It comes from the benzodiazepine class of drugs and works by increasing the activity of the GABA neurotransmitter in the brain.
Midazolam was patented in 1974 and entered into medical usage in 1982.

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It is on the World Health Organization’s List of Necessary Medicines. Midazolam is offered as a generic medication.  In many nations, it is an illegal drug.

A midazolam overdose is thought about a medical emergency situation and typically needs the immediate attention of medical personnel. Benzodiazepine overdose in healthy individuals is rarely lethal with correct medical support; nevertheless, the toxicity of benzodiazepines increases when they are integrated with other CNS depressants such as alcohol, opioids, or tricyclic antidepressants.

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The toxicity of benzodiazepine overdose and the risk of death are likewise increased in the elderly and those with obstructive lung disease or when utilized intravenously. Treatment is supportive; activated charcoal can be utilized within an hour of the overdose. The remedy for an overdose of midazolam (or any other benzodiazepine) is flumazenil.

While efficient in reversing the impacts of benzodiazepines it is not utilized in many cases as it may activate seizures in combined overdoses and benzodiazepine dependent people.

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Signs of midazolam overdose can include:
Ataxia
Dysarthria
Nystagmus
Slurred speech
Somnolence (problem staying awake).
Mental confusion.
Hypotension.
Breathing arrest.
Vasomotor collapse.
Impaired motor functions.
Impaired reflexes.
Impaired coordination.
Impaired balance.
Lightheadedness.
Coma.
Death.

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